Julian John Thurstan Gough (born 1974) is a Group Leader in the

Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

(LMB) of the Medical Research Council (MRC). He was previously a professor of

bioinformatics Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...

at the

University of Bristol , mottoeng = earningpromotes one's innate power (from Horace, ''Ode 4.4'') , established = 1595 – Merchant Venturers School1876 – University College, Bristol1909 – received royal charter , type ...

Education

Gough was educated at

The Perse School (He who does things for others does them for himself) , established = , closed = , type = Public schoolIndependent day school , religion = Nondenominational Christian , president = , head_label = Head , he ...

Cambridge Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge bec ...

and the

where he was awarded a

joint honours degree A joint honours degree (also known as dual honours, double majors, or Two Subject Moderatorship) is a specific type of degree offered generally at the Honours Bachelor's degree level by certain universities in Ireland, the UK, Canada, Malta, and ...

in Mathematics and

Physics Physics is the natural science that studies matter, its fundamental constituents, its motion and behavior through space and time, and the related entities of energy and force. "Physical science is that department of knowledge which r ...

in 1998. He went on to complete his PhD in the

(LMB) supervised by

Cyrus Chothia Cyrus Homi Chothia (19 February 1942 – 26 November 2019) was an English biochemist who was an emeritus scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge and emeritus fellow ...

on genome analysis and

protein structure Protein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers specifically polypeptides formed from sequences of amino acids, the monomers of the polymer. A single amino acid monomer ma ...

as a postgraduate student of

Sidney Sussex College, Cambridge Sidney Sussex College (referred to informally as "Sidney") is a constituent college of the University of Cambridge in England. The College was founded in 1596 under the terms of the will of Frances Sidney, Countess of Sussex (1531–1589), wife ...

, graduating in 2001.

Career and research

Following his PhD, Gough completed

postdoctoral research A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to p ...

at the LMB and

Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...

, with

Michael Levitt Michael Levitt, ( he, מיכאל לויט; born 9 May 1947) is a South African-born biophysicist and a professor of structural biology at Stanford University, a position he has held since 1987. Levitt received the 2013 Nobel Prize in Chemistr ...

. Subsequently, he was a scientist at RIKEN in Tokyo before being appointed a member of faculty at the

, where he has worked since 2007. He has also been a visiting scientist at the

Pasteur Institute The Pasteur Institute (french: Institut Pasteur) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines f ...

in Paris and an

associate professor Associate professor is an academic title with two principal meanings: in the North American system and that of the ''Commonwealth system''. Overview In the ''North American system'', used in the United States and many other countries, it is a ...

Tokyo Medical and Dental University is a Japanese national university located in Bunkyō, Tokyo, Japan. Established in 1928, it was the first national school of dentistry in Japan. TMDU is one of top 9 Designated National University and selected as a Top Type university of Top Gl ...

. Gough's research interests are in

computational biology Computational biology refers to the use of data analysis, mathematical modeling and computational simulations to understand biological systems and relationships. An intersection of computer science, biology, and big data, the field also has fo ...

molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

genomics Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes as well as its hierarchical, three-dim ...

which has led to the creation of the

Superfamily database SUPERFAMILY is a database and search platform of structural and functional annotation for all proteins and genomes. It classifies amino acid sequences into known structural domains, especially into SCOP superfamilies. Domains are functional, str ...

Hidden Markov model A hidden Markov model (HMM) is a statistical Markov model in which the system being modeled is assumed to be a Markov process — call it X — with unobservable ("''hidden''") states. As part of the definition, HMM requires that there be an ob ...

s (HMMs) representing all proteins of known structure. His research has been published in leading

peer review Peer review is the evaluation of work by one or more people with similar competencies as the producers of the work (peers). It functions as a form of self-regulation by qualified members of a profession within the relevant field. Peer review ...

scientific journal In academic publishing, a scientific journal is a periodical publication intended to further the progress of science, usually by reporting new research. Content Articles in scientific journals are mostly written by active scientists such as s ...

s including ''

Nature Nature, in the broadest sense, is the physics, physical world or universe. "Nature" can refer to the phenomenon, phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. ...

'', ''

Science Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence for ...

'', ''

Cell Cell most often refers to: * Cell (biology), the functional basic unit of life Cell may also refer to: Locations * Monastic cell, a small room, hut, or cave in which a religious recluse lives, alternatively the small precursor of a monastery ...

'', ''

Nucleic Acids Research ''Nucleic Acids Research'' is an open-access peer-reviewed scientific journal published since 1974 by the Oxford University Press. The journal covers research on nucleic acids, such as DNA and RNA, and related work. According to the ''Journal Cit ...

'', ''

PNAS ''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Scien ...

'', the ''

Biochemical Journal The ''Biochemical Journal'' is a peer-reviewed scientific journal which covers all aspects of biochemistry, as well as cell and molecular biology. It is published by Portland Press and was established in 1906. History The journal was established i ...

'', the ''

Journal of Molecular Biology The ''Journal of Molecular Biology'' is a biweekly peer-reviewed scientific journal covering all aspects of molecular biology. It was established in 1959 and is published by Elsevier. The editor-in-chief is Peter Wright ( The Scripps Research In ...

'', ''

Genome Research ''Genome Research'' is a peer-reviewed scientific journal published by Cold Spring Harbor Laboratory Press. Disregarding review journals, Genome Research ranks 2nd in the category 'Genetics and Genomics' after Nature Genetics. The focus of the jou ...

'', ''

Bioinformatics Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...

'', ''

PLOS Genetics ''PLOS Genetics'' is a peer-reviewed open access scientific journal established in 2005 and published by the Public Library of Science. The founding editor-in-chief was Wayne N. Frankel (Columbia University Medical Center). The current editors-in ...

'', ''

Nature Genetics ''Nature Genetics'' is a peer-reviewed scientific journal published by Nature Portfolio. It was established in 1992. It covers research in genetics. The chief editor is Tiago Faial. The journal encompasses genetic and functional genomic studi ...

'' and the ''

Journal of Bacteriology The ''Journal of Bacteriology'' is a biweekly peer-reviewed scientific journal established in 1916. It is published by the American Society for Microbiology and the editor in chief is George A. O'Toole (Dartmouth College). The journal is delayed ...

''. Gough's research has been funded by the

Biotechnology and Biological Sciences Research Council Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation, is a non-departmental public body (NDPB), and is the largest UK public funder of non-medical bioscience. It predominantly funds scientific rese ...

(BBSRC), the

Engineering and Physical Sciences Research Council The Engineering and Physical Sciences Research Council (EPSRC) is a British Research Council that provides government funding for grants to undertake research and postgraduate degrees in engineering and the physical sciences, mainly to universi ...

(EPSRC), the

Natural Environment Research Council The Natural Environment Research Council (NERC) is a British research council that supports research, training and knowledge transfer activities in the environmental sciences. History NERC began in 1965 when several environmental (mainly geogr ...

(NERC), the

European Union The European Union (EU) is a supranational political and economic union of member states that are located primarily in Europe. The union has a total area of and an estimated total population of about 447million. The EU has often been des ...

(EU) Seventh Research Framework Programme (FP7), the

Japan Society for the Promotion of Science The is an Independent Administrative Institution in Japan, established for the purpose of contributing to the advancement of science in all fields of the natural and social sciences and the humanities.JSPSweb page History The Japan Society for ...

(JSPS) and the

Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

of London. His former doctoral students and postdocs include Ralph Pethica, Owen Rackham, Hashem Shihab, Matt Oates, and Dimitrios Vavoulis.

References

{{DEFAULTSORT:Gough, Julian John Thurstan People educated at The Perse School British bioinformaticians Alumni of the University of Bristol Alumni of Sidney Sussex College, Cambridge Living people 1974 births